参考文献

1.Kheifets V,Mochly-Rosen D. Insight into intra- and inter-molecular interactions of PKC:design of specific modulators of kinase function.Pharmacol Res,2007,55(6):467-476.
2.Martiny-Baron G,Fabbro D.Classical PKC isoforms in cancer.Pharmacol Res,2007,55(6):477-486.
3.高志强,韩宝惠.蛋白激酶C抑制剂与非小细胞肺癌的治疗.中国肺癌杂志,2009,12(1):68-72.
4.Graham MA,Rawe I,Dartt DA,et al.Protein kinase C regulation of corneal endothelial cell proliferation and cell cycle.Invest Ophthalmol Vis Sci,2000,41(13):4124-4132.
5.Wang JH,Redmond HP,Watson RW,et al.Involvement of tyrosine protein kinase in IFN-gamma-induced human endothelial cell apoptosis. Shock(Augusta,Ga.),1999,11(5):311-318.
6.Regala RP,Weems C,Jamieson L,et al. Atypical protein kinase C iota is an oncogene in human non-small cell lung cancer. Cancer Res,2005,65(19):8905-8911.
7.Villalona-Calero MA,Ritch P,Figueroa JA,et al. A phaseⅠ/Ⅱ study of LY900003,an antisense inhibitor of protein kinase C-alpha,in combination with cisplatin and gemcitabine in patients with advanced non-small cell lung cancer. Clin Cancer Res,2004,10(18 Pt 1):6086-6093.
8.Monnerat C,Henriksson R,Le CT,et al. Phase I study of PKC412(N-benzoyl-staurosporine),a novel oral protein kinase C inhibitor,combined with gemcitabine and cisplatin in patients with non-small-cell lung cancer.Annals of oncology:official journal of the European Society for Medical Oncology/ESMO.2004.15(2):316-323.
9.Lara PN Jr,Mack PC,Synold T,et al. The cyclin-dependent kinase inhibitor UCN-01 plus cisplatin in advanced solid tumors:a California cancer consortium phaseⅠ pharmacokinetic and molecular correlative trial.Clin Cancer Res,2005,11(12):4444-4450.
10.Edelman MJ,Bauer KS Jr,Wu S,et al.PhaseⅠand pharmacokinetic study of 7-hydroxystaurosporine and carboplatin in advanced solid tumors. Clin Cancer Res,2007,13(9):2667-2674.
11.Winegarden JD,Mauer AM,Gajewski TF,et al.A phase Ⅱstudy of bryostatin-1 and paclitaxel in patients with advanced non-small cell lung cancer. Lung cancer(Amsterdam,Netherlands),2003,39(2):191-196.
12.任伟宏,吴景兰.蛋白激酶与细胞凋亡信号及凋亡抑制信号的转导.国外医学(临床生物化学与检验学分册),2004,25(1):79-82.
13.马强,张振书.蛋白激酶C对多药耐药调控作用.生命的化学,2001,21(4):174-176.
14.周清华,刘伦旭,李潞,等.PKC基因在人肺癌中的转录表达.中国肺癌杂志,2000,3(5):351-354.
15.程玺,周清华,王允,等.人非小细胞肺癌中蛋白激酶CβⅠ的表达及细胞凋亡与预后关系的研究.中国肺癌杂志,2004,7(5):404-408.
16.高志强,杨晓华,冯久贤,等.非小细胞肺癌中蛋白激酶C-α的表达及其意义.肿瘤,2007,27(12):981-984.
17.徐学萍,肖殿模.蛋白激酶C抑制剂的研究概况.国外医学:药学分册. 1994.21(2):86-91.
18.Jemal A,Siegel R,Xu J,et al. Cancer statistics,2010.CA Cancer J Clin,2010,60(5):277-300.
19.Thun MJ,Henley SJ,Burns D,et al.Lung cancer death rates in lifelong nonsmokers. J Natl Cancer Inst,2006,98(10):691-699.
20.Jemal A,Bray F,Center MM,et al. Global cancer statistics. CA Cancer J Clin,2011,61(2):69-90.
21.Nishizuka Y. Intracellular signaling by hydrolysis of phospholipids and activation of protein kinase C. Science,1992,258(5082):607-614.
22.Nishizuka Y.Protein kinase C and lipid signaling for sustained cellular responses. FASEB J,1995,9(7):484-496.
23.Duquesnes N,Lezoualc’h F,Crozatier B. PKC-delta and PKC-epsilon:foes of the same family or strangers.J Mol Cell Cardiol,2011,51(5):665-673.
24.Giorgi C,Agnoletto C,Baldini C,et al. Redox control of protein kinase C:cell- and disease-specific aspects. Antioxid Redox Signal,2010,13(7):1051-1085.
25.Gopalakrishna R,Jaken S. Protein kinase C signaling and oxidative stress. Free Radic Biol Med,2000,28(9):1349-1361.
26.Kikkawa U,Kishimoto A,Nishizuka Y. The protein kinase C family:heterogeneity and its implications.Annu Rev Biochem,1989,58:31-44.
27.Svetek J,Schara M,Pecar S,et al.Spectroscopic characterization of specific phorbol ester binding to PKC-receptor sites in membranes in situ. Carcinogenesis,1995,16(10):2589-2592.
28.Rosse C,Linch M,Kermorgant S,et al. PKC and the control of localized signal dynamics. Nat Rev Mol Cell Biol,2010,11(2):103-112.
29.Cenni V,Doppler H,Sonnenburg ED,et al. Regulation of novel protein kinase C epsilon by phosphorylation. Biochem J,2002,363(Pt 3):537-545.
30.Pfeifhofer-Obermair C,Thuille N,Baier G. Involvement of distinct PKC gene products in T cell functions. Front Immunol,2012,3:220.
31.Zhang EY,Kong KF,Altman A. The yin and yang of protein kinase C-theta(PKCθ):a novel drug target for selective immunosuppression.Adv Pharmacol,2013,66:267-312.
32.Quann EJ,Liu X,Altan-Bonnet G,et al.A cascade of protein kinase C isozymes promotes cytoskeletal polarization in T cells.Nat Immunol,2011,12(7):647-654.
33.Fu G,Gascoigne NR. The role of protein kinase cηin T cell biology.Front Immunol,2012,3:177.
34.Rimessi A,Patergnani S,Ioannidi E,et al.Chemoresistance and Cancer-Related Inflammation:Two Hallmarks of Cancer Connected by an Atypical Link,PKCζ. Front Oncol,2013,3:232.
35.Breitkreutz D,Braiman-Wiksman L,Daum N,et al.Protein kinase C family:on the crossroads of cell signaling in skin and tumor epithelium. J Cancer Res Clin Oncol,2007,133(11):793-808.
36.Miyamae M,Rodriguez MM,Camacho SA,et al. Activation of epsilon protein kinase C correlates with a cardioprotective effect of regular ethanol consumption. Proc Natl Acad Sci U S A,1998,95(14):8262-8267.
37.Benoit SC,Kemp CJ,Elias CF,et al.Palmitic acid mediates hypothalamic insulin resistance by altering PKC-theta subcellular localization in rodents.J Clin Invest,2009,119(9):2577-2589.
38.Oyasu M,Fujimiya M,Kashiwagi K,et al. Immunogold electron microscopic demonstration of distinct submembranous localization of the activated gammaPKC depending on the stimulation.J Histochem Cytochem,2008,56(3):253-265.
39.Almeida-Amaral EE,Caruso-Neves C,Lara LS,et al.Leishmania amazonensis:PKC-like protein kinase modulates the(Na++K+)ATPase activity.Exp Parasitol,2007,116(4):419-426.
40.Rimessi A,Zecchini E,Siviero R,et al.The selective inhibition of nuclear PKCζ restores the effectiveness of chemotherapeutic agents in chemoresistant cells.Cell cycle(Georgetown,Tex.),2012,11(5):1040-1048.
41.Rimessi A,Rizzuto R,Pinton P. Differential recruitment of PKC isoforms in HeLa cells during redox stress.Cell Stress Chaperones,2007,12(4):291-298.
42.McKernan LN,Momjian D,Kulkosky J. Protein Kinase C:One Pathway towards the Eradication of Latent HIV-1 Reservoirs.Adv Virol,2012,2012:805347.
43.Steinberg SF.Structural basis of protein kinase C isoform function.Physiol Rev,2008,88(4):1341-1378.
44.Spitaler M,Cantrell DA.Protein kinase C and beyond. Nat Immunol,2004,5(8):785-790.
45.Rybin VO,Guo J,Harleton E,et al. Regulatory autophosphorylation sites on protein kinase C-delta at threonine-141 and threonine-295.Biochemistry,2009,48(21):4642-4651.
46.Sadana R,Dessauer CW.Physiological roles for G protein-regulated adenylyl cyclase isoforms:insights from knockout and overexpression studies. Neurosignals,2009,17(1):5-22.
47.Willoughby D,Cooper DM.Organization and Ca 2+ regulation of adenylyl cyclases in cAMP microdomains.Physiol Rev,2007,87(3):965-1010.
48.Pollak MN,Schernhammer ES,Hankinson SE.Insulin-like growth factors and neoplasia. Nat Rev Cancer,2004,4(7):505-518.
49.Oh SH,Whang YM,Min HY,et al. Histone deacetylase inhibitors enhance the apoptotic activity of insulin-like growth factor binding protein-3 by blocking PKC-induced IGFBP-3 degradation.Int J Cancer,2012,131(10):2253-2263.
50.Geraldes P,King GL. Activation of protein kinase C isoforms and its impact on diabetic complications.Circ Res,2010,106(8):1319-1331.
51.Toton E,Ignatowicz E,Skrzeczkowska K,et al. Protein kinase Cepsilon as a cancer marker and target for anticancer therapy.Pharmacol Rep,2011,63(1):19-29.
52.Inagaki K,Churchill E,Mochly-Rosen D.Epsilon protein kinase C as a potential therapeutic target for the ischemic heart.Cardiovasc Res,2006,70(2):222-230.
53.Ferreira JC,Brum PC,Mochly-Rosen D. βⅡPKC and εPKC isozymes as potential pharmacological targets in cardiac hypertrophy and heart failure.J Mol Cell Cardiol,2011,51(4):479-484.
54.Zanin-Zhorov A,Dustin ML,Blazar BR. PKC-theta function at the immunological synapse:prospects for therapeutic targeting.Trends Immunol,2011,32(8):358-363.
55.Burguillos MA,Deierborg T,Kavanagh E,et al. Caspase signalling controls microglia activation and neurotoxicity.Nature,2011,472(7343):319-324.
56.Zhang D,Anantharam V,Kanthasamy A,et al.Neuroprotective effect of protein kinase C delta inhibitor rottlerin in cell culture and animal models of Parkinson’s disease. J Pharmacol Exp Ther,2007,322(3):913-922.
57.Garrido JL,Godoy JA,Alvarez A,et al.Protein kinase C inhibits amyloid beta peptide neurotoxicity by acting on members of the Wnt pathway. FASEB J,2002,16(14):1982-1984.
58.Manji HK,Lenox RH.The nature of bipolar disorder. J Clin Psychiatry,2000,61(Supp 13):42-57.
59.Zarate CA,Manji HK.Protein kinase C inhibitors:rationale for use and potential in the treatment of bipolar disorder.CNS Drugs,2009,23(7):569-582.
60.Maioli E,Valacchi G.Rottlerin:bases for a possible usage in psoriasis. Curr Drug Metab,2010,11(5):425-430. 61.Urtreger AJ,Kazanietz MG,Bal de Kier Joffe ED.Contribution of individual PKC isoforms to breast cancer progression.IUBMB Life,2012,64(1):18-26.
62.Michie AM,Nakagawa R.The link between PKCalpha regulation and cellular transformation. Immunol Lett,2005,96(2):155-162.
63.Sledge GW Jr,Gokmen-Polar Y. Protein kinase C-beta as a therapeutic target in breast cancer.Semin Oncol,2006,33(3):S15-18.
64.Kim J,Koyanagi T,Mochly-Rosen D. PKCδ activation mediates angiogenesis via NADPH oxidase activity in PC-3 prostate cancer cells. Prostate,2011,71(9):946-954.
65.Bacher N,Zisman Y,Berent E,et al.Isolation and characterization of PKC-L,a new member of the protein kinase C-related gene family specifically expressed in lung,skin,and heart.Mol Cell Biol,1991,11(1):126-133. 66.Krasnitsky E,Baumfeld Y,Freedman J,et al.PKCη is a novel prognostic marker in non-small cell lung cancer. Anticancer Res,2012,32(4):1507-1513.
67.Benavides F,Blando J,Perez CJ,et al. Transgenic overexpression of PKC epsilon in the mouse prostate induces preneoplastic lesions. Cell cycle(Georgetown,Tex.),2011,10(2):268-277.
68.Dittmann K,Mayer C,Rodemann HP. Nuclear EGFR as novel therapeutic target:insights into nuclear translocation and function.Strahlenther Onkol,2010,186(1):1-6.
69.Griner EM,Kazanietz MG. Protein kinase C and other diacylglycerol effectors in cancer. Nat Rev Cancer,2007,7(4):281-294.
70.Meng QH,Zhou LX,Luo JL,et al.Effect of 7-hydroxystaurosporine on glioblastoma cell invasion and migration. Acta Pharmacol Sin,2005,26(4):492-499.
71.Tsai CH,Hsieh YS,Yang SF,et al. Matrix metalloproteinase 2 and matrix metalloproteinase 9 expression in human oral squamous cell carcinoma and the effect of protein kinase C inhibitors:preliminary observations.Oral surgery,oral medicine,oral pathology,oral radiology,and endodontics,2003,95(6):710-716.
72.Caino MC,Lopez-Haber C,Kim J,et al. Proteins kinase Cvarepsilon is required for non-small cell lung carcinoma growth and regulates the expression of apoptotic genes. Oncogene,2012,31(20):2593-2600.
73.Caino MC,Meshki J,Kazanietz MG.Hallmarks for senescence in carcinogenesis:novel signaling players. Apoptosis,2009,14(4):392-408.
74.Oliva JL,Caino MC,Senderowicz AM,et al.S-Phase-specific activation of PKC alpha induces senescence in non-small cell lung cancer cells.J Biol Chem,2008,283(9):5466-5476.
75.Bae KM,Wang H,Jiang G,et al. Protein kinase C epsilon is over expressed in primary human non-small cell lung cancers and functionally required for proliferation of non-small cell lung cancer cells in a p21/Cip1-dependent manner.Cancer Res,2007,67(13):6053-6063.
76.Basu A,Sivaprasad U.Protein kinase Cepsilon makes the life and death decision. Cell Signal,2007,19(8):1633-1642.
77.Felber M,Sonnemann J,Beck JF. Inhibition of novel protein kinase C-epsilon augments TRAIL-induced cell death in A549 lung cancer cells.Pathol Oncol Res,2007,13(4):295-301.
78.Gorin MA,Pan Q.Protein kinase C epsilon:an oncogene and emerging tumor biomarker.Mol Cancer,2009,8:9.
79.Caino MC,Lopez-Haber C,Kissil JL,et al.Non-small cell lung carcinoma cell motility,rac activation and metastatic dissemination are mediated by protein kinase C epsilon. PLoS One,2012,7(2):e31714.
80.Hong SH,Ren L,Mendoza A,et al. Apoptosis resistance and PKC signaling:distinguishing features of high and low metastatic cells. Neoplasia,2012,14(3):249-258.
81.Gao ZQ,Han BH,Sha HF,et al.Effects of a protein kinase C inhibitor combined with cisplatin on non-small cell lung cancer.Zhonghua Jie He He Hu Xi Za Zhi.2010,33(4):284-288.
82.Bowling N,Walsh RA,Song G,et al.Increased protein kinase C activity and expression of Ca2+-sensitive isoforms in the failing human heart.Circulation,1999,99(3):384-391.
83.Nishikawa T,Edelstein D,Brownlee M.The missing link:a single unifying mechanism for diabetic complications. Kidney Int Suppl,2000,77:S26-30.
84.Podar K,Raab MS,Chauhan D,et al.The therapeutic role of targeting protein kinase C in solid and hematologic malignancies. Expert Opin Investig Drugs,2007,16(10):1693-1707.
85.Ali AS,Ali S,El-Rayes BF,et al. Exploitation of protein kinase C:a useful target for cancer therapy.Cancer Treat Rev,2009,35(1):1-8.
86.Reyland ME.Protein kinase C isoforms:Multi-functional regulators of cell life and death. Frontiers in bioscience(Landmark edition),2009,14:2386-2399.
87.Bosco R,Melloni E,Celeghini C,et al. Fine tuning of protein kinase C(PKC) isoforms in cancer:shortening the distance from the laboratory to the bedside.Mini Rev Med Chem,2011,11(3):185-199.
88.DiazGranados N,Zarate CA Jr.A review of the preclinical and clinical evidence for protein kinase C as a target for drug development for bipolar disorder. Curr Psychiatry Rep,2008,10(6):510-519.
89.Teicher BA. Protein kinase C as a therapeutic target. Clin Cancer Res,2006,12(18):5336-5345.
90.Budas GR,Churchill EN,Mochly-Rosen D.Cardioprotective mechanisms of PKC isozyme-selective activators and inhibitors in the treatment of ischemia-reperfusion injury.Pharmacol Res,2007,55(6) 523-536.
91.Pravdic D,Sedlic F,Mio Y,et al.Anesthetic-induced preconditioning delays opening of mitochondrial permeability transition pore via protein Kinase C-epsilon-mediated pathway.Anesthesiology,2009,111(2):267-274.
92.Ding RQ,Tsao J,Chai H,et al. Therapeutic potential for protein kinase C inhibitor in vascular restenosis. J Cardiovasc Pharmacol Ther,2011,16(2):160-167.
93.Pang X,Sun NL. Calcineurin-NFAT signaling is involved in phenylephrine-induced vascular smooth muscle cell proliferation. Acta Pharmacol Sin,2009,30(5):537-544.
94.Mochly-Rosen D,Das K,Grimes KV. Protein kinase C,an elusive therapeutic target.Nat Rev Drug Discov,2012,11(12):937-957.
95.Socinski MA,Raju RN,Stinchcombe T,et al. Randomized,phase Ⅱ trial of pemetrexed and carboplatin with or without enzastaurin versus docetaxel and carboplatin as first-line treatment of patients with stage ⅢB/Ⅳ nonsmall cell lung cancer. J Thorac Oncol,2010,5(12):1963-1969.
96.Carducci MA,Musib L,Kies MS,et al. Phase Ⅰ dose escalation and pharmacokinetic study of enzastaurin,an oral protein kinase C beta inhibitor,in patients with advanced cancer. J Clin Oncol,2006,24(25):4092-4099.
97.Hanauske AR,Oberschmidt O,Hanauske-Abel H,et al. Antitumor activity of enzastaurin(LY317615.HCl)against human cancer cell lines and freshly explanted tumors investigated in in-vitro [corrected] soft-agar cloning experiments. Invest New Drugs,2007,25(3):205-210.
98.Korner A,Mudduluru G,Manegold C,et al. Enzastaurin inhibits invasion and metastasis in lung cancer by diverse molecules. Br J Cancer,2010,103(6):802-811.
99.Willey CD,Xiao D,Tu T,et al. Enzastaurin(LY317615),a protein kinase C beta selective inhibitor,enhances antiangiogenic effect of radiation. Int J Radiat Oncol Biol Phys,2010,77(5):1518-1526.
100.Ma S,Rosen ST. Enzastaurin. Curr Opin Oncol,2007,19(6):590-595.
101.Robertson MJ,Kahl BS,Vose JM,et al. PhaseⅡ study of enzastaurin,a protein kinase C beta inhibitor,in patients with relapsed or refractory diffuse large B-cell lymphoma. J Clin Oncol,2007,25(13):1741-1746.
102.Meng XW,Heldebrant MP,Flatten KS,et al. Protein kinase Cbeta modulates ligand-induced cell surface death receptor accumulation:a mechanistic basis for enzastaurin-death ligand synergy. J Biol Chem,2010,285(2):888-902.
103.Ruvolo PP,Zhou L,Watt JC,et al. Targeting PKC-mediated signal transduction pathways using enzastaurin to promote apoptosis in acute myeloid leukemia-derived cell lines and blast cells. J Cell Biochem. 2011,112(6):1696-707.
104.Wang Y,Yang H,Liu H,et al. Effect of staurosporine on the mobility and invasiveness of lung adenocarcinoma A549 cells:an in vitro study. BMC Cancer,2009,9:174.
105.Entschladen F,Drell TL 4th,Lang K,et al. Neurotransmitters and chemokines regulate tumor cell migration:potential for a new pharmacological approach to inhibit invasion and metastasis development. Curr Pharm Des,2005,11(3):403-411.
106.Zhang YX,Yu SB,Ou-Yang JP,et al. Effect of protein kinase C alpha,caspase-3,and survivin on apoptosis of oral cancer cells induced by staurosporine. Acta Pharmacol Sin,2005,26(11):1365-1372.
107.Mackay HJ,Twelves CJ. Targeting the protein kinase C family:are we there yet. Nat Rev Cancer,2007,7(7):554-562.
108.Rini BI,Weinberg V,Shaw V,et al. Time to disease progression to evaluate a novel protein kinase C inhibitor,UCN-01,in renal cell carcinoma. Cancer,2004,101(1):90-95.
109.Welch S,Hirte HW,Carey MS,et al. UCN-01 in combination with topotecan in patients with advanced recurrent ovarian cancer:a study of the Princess Margaret Hospital Phase Ⅱ consortium. Gynecol Oncol,2007,106(2):305-310.
110.Kim YM,Jeong IH,Pyo H. Celecoxib enhances the radiosensitizing effect of 7-hydroxystaurosporine(UCN-01)in human lung cancer cell lines. Int J Radiat Oncol Biol Phys,2012,83(3):e399-407.
111.Hewson CA,Edbrooke MR,Johnston SL. PMA induces the MUC5AC respiratory mucin in human bronchial epithelial cells,via PKC,EGF/TGF-alpha,Ras/Raf,MEK,ERK and Sp1-dependent mechanisms. J Mol Biol,2004,344(3):683-695.
112.Stahl S,Kaminskyy VO,Efazat G,et al. Inhibition of Ephrin B3-mediated survival signaling contributes to increased cell death response of non-small cell lung carcinoma cells after combined treatment with ionizing radiation and PKC 412.Cell Death Dis,2013,4:e454.
113.Robins HI,Won M,Seiferheld WF,et al. Phase 2 trial of radiation plus high-dose tamoxifen for glioblastoma multiforme:RTOG protocol BR-0021.Neuro Oncol,2006,8(1):47-52.
114.Philip PA,Rea D,Thavasu P,et al. Phase I study of bryostatin 1:assessment of interleukin 6 and tumor necrosis factor alpha induction in vivo. The Cancer Research Campaign Phase Ⅰ Committee. J Natl Cancer Inst,1993,85(22):1812-1818.
115.Lam AP,Sparano JA,Vinciguerra V,et al. Phase Ⅱ study of paclitaxel plus the protein kinase C inhibitor bryostatin-1 in advanced pancreatic carcinoma. Am J Clin Oncol,2010,33(2):121-124.
116.Nezhat F,Wadler S,Muggia F,et al. Phase Ⅱ trial of the combination of bryostatin-1 and cisplatin in advanced or recurrent carcinoma of the cervix:a New York Gynecologic Oncology Group study. Gynecol Oncol,2004,93(1):144-148.
117.Ku GY,Ilson DH,Schwartz LH,et al. Phase Ⅱ trial of sequential paclitaxel and 1 h infusion of bryostatin-1 in patients with advanced esophageal cancer. Cancer Chemother Pharmacol,2008,62(5):875-880.
118.Ajani JA,Jiang Y,Faust J,et al. A multi-center phase Ⅱ study of sequential paclitaxel and bryostatin-1(NSC 339555) in patients with untreated,advanced gastric or gastroesophageal junction adenocarcinoma. Invest New Drugs,2006,24(4):353-357.
119.Cripps MC,Figueredo AT,Oza AM,et al. Phase Ⅱ randomized study of ISIS 3521 and ISIS 5132 in patients with locally advanced or metastatic colorectal cancer:a National Cancer Institute of Canada clinical trials group study. Clin Cancer Res,2002,8(7):2188-2192.
120.Tolcher AW,Reyno L,Venner PM,et al. A randomized phase Ⅱ and pharmacokinetic study of the antisense oligonucleotides ISIS 3521 and ISIS 5132 in patients with hormone-refractory prostate cancer. Clin Cancer Res,2002,8(8):2530-2535.
121.Marshall JL,Eisenberg SG,Johnson MD,et al. A phase Ⅱ trial of ISIS 3521 in patients with metastatic colorectal cancer. Clin Colorectal Cancer,2004,4(4):268-274.
122.Advani R,Lum BL,Fisher GA,et al. A phase Ⅰ trial of aprinocarsen(ISIS 3521/LY900003),an antisense inhibitor of protein kinase C-alpha administered as a 24-hour weekly infusion schedule in patients with advanced cancer. Invest New Drugs,2005,23(5):467-477.
123.Rao S,Watkins D,Cunningham D,et al. Phase Ⅱ study of ISIS 3521,an antisense oligodeoxynucleotide to protein kinase C alpha,in patients with previously treated low-grade non-Hodgkin’s lymphoma. Annals of oncology:official journal of the European Society for Medical Oncology / ESMO,2004,15(9):1413-1418.
124.Paz-Ares L,Douillard JY,Koralewski P,et al. Phase Ⅲ study of gemcitabine and cisplatin with or without aprinocarsen,a protein kinase C-alpha antisense oligonucleotide,in patients with advanced-stage non-smallcell lung cancer. J Clin Oncol,2006,24(9):1428-1434.
125.Gschwendt M,Muller HJ,Kielbassa K,et al. Rottlerin,a novel protein kinase inhibitor. Biochem Biophys Res Commun,1994,199(1):93-98.
126.Davis MI,Hunt JP,Herrgard S,et al.Comprehensive analysis of kinase inhibitor selectivity. Nat Biotechnol,2011,29(11):1046-1051.
127.Halls ML,Cooper DM.Regulation by Ca2+-signaling pathways of adenylyl cyclases. Cold Spring Harb Perspect Biol,2011,3(1):a004143.