参考文献

1.Chang J Y，Komaki R，Lu C，et al.Phase Ⅱ Study of High-Dose Proton Therapy with Concurrent Chemotherapy for Unresectable Stage ⅡI Non-Small Cell Lung Cancer.Cancer，2011，117（20）：4707-4713.

2.Murphy ES，Merchant TE，Wu S，et al.Necrosis after craniospinal irradiation：Results from a prospective series of children with central nervous system embryonal tumors.Int J Radiat Oncol Biol Phys，2012，83 ：e655-e660.

3.Okada T，Tsuji H，Kamada T，et al.Carbon Ion Radiotherapy in Advanced Hypofractionated Regimens for Prostate Cancer：From 20 to 16 Fractions.Int J Radiat Oncol Biol Phys，2012，84（4）：968-972.

4.Edward C.Halperin，David E.Wazer，et al.Brady.Perez and Brady’s Principles and Practice of Radiation Oncology.6th ed.Lippincott Williams & Wilkins，2013.

5.Toyama S，Tsuji H，Mizoguchi N，et al.Long-term Result of Carbon-ion Radiation Therapy for Locally Advanced or Unfavorably Located Choroidal Melanoma：CT Based 2-port Orthogonal Therapy Can Reduce the Incidence of Neovascular Glaucoma.Int J Radiat Oncol Biol Phys，2013，86（2）：270-276.

6.Tsujii H，Kamada T，Shirai T，et al.Carbon-Ion Radiotherapy：Principles，Practices，and Treatment Planning.Springer Japan，2014.

7.Greenberger B A，Pulsifer M B，Ebb D H，et al.Clinical outcomes and late endocrine，neurocognitive，and visual profiles of proton radiation for pediatric low-grade gliomas.Int J Radiat Oncol Biol Phys，2014，89（5）：1060-1068.

8.Sethi R V，Shih H A，Yeap B Y，et al.Second nonocular tumors among survivors of retinoblastoma treated with contemporary photon and proton radiotherapy.Cancer，2014，120（1）：126-133.

9.Kanemoto A，Okumura T，Ishikawa H，et al.Outcomes and prognostic factors for recurrence after high-dose proton beam therapy for centrally and peripherally located stage I non-small-cell lung cancer.Clin Lung Cancer，2014，15（2）：7-12.

10.Nguyen Q N，Ly N B，Komaki R，et al.Long-term outcomes after proton therapy，with concurrent chemotherapy，for stage Ⅱ- Ⅲinoperable non-small cell lung cancer.Radiother Oncol，2015，115（3）：367-372.

11.Kamada T，Tsujii H，Blakely E A，et al.Carbon ion radiotherapy in Japan：an assessment of 20 years of clinical experience.Lancet Oncol，2015，16（2）：e93-e100.

12.Habl G，Uhl M，Katayama S，et al.Acute Toxicity and Quality of Life in Patients With Prostate Cancer Treated With Protons or Carbon Ions in a Prospective Randomized Phase Ⅱ Study-The IPI Trial.Int J Radiat Oncol Biol Phys，2016，95（1）：435-43.

13.Shinoto M，Ebner D K，Yamada S.Particle Radiation Therapy for Gastrointestinal Cancers.Curr Oncol Rep，2016，18（3）：1-9.

14.Giantsoudi D，Sethi R V，Yeap B Y，et al.Incidence of CNS Injury for a Cohort of 111 Patients Treated With Proton Therapy for Medulloblastoma：LET and RBE Associations for Areas of Injury.Int J Radiat Oncol Biol Phys，2016，95（1）：287-96.

15.Weber DC et al.Proton therapy for pediatric malignancies：Fact，figures and costs.A joint consensus statement from the pediatric subcommittee of PTCOG，PROS and EPTN.Radiother Oncol，2018，128（1）：44-55.