参考文献

1.郝伟,于欣.精神病学.7版.北京:人民卫生出版社,2013

2.沈渔邨.精神病学.5版.北京:人民卫生出版社,2009

3.范建华,沈渔邨,周朝凤,等.汉族酒依赖高发家系单胺氧化酶A基因多态性的对照研究.中华精神科杂志,1999,32(3):160-163

4.Wang J,Carnicella S,Phamluong K,et al.Ethanol induces long-term facilitation of NR2B-NMDA receptor activity in the dorsal striatum: implications for alcohol drinking behavior.Neurosci 2007 27:3593-3602

5.Sheela Rani CS,Ticku MK.Comparison of chronic ethanol and chronic intermittent ethanol treatments on the expression of GABA(A)and NMDA receptor subunits.Alcohol 2006,38:89-97

6.Boyce-Rustay JM,Holmes A.Ethanol-related behaviors in mice lacking the NMDA receptor NR2A subunit.Psychopharmacology,2006,187:455-466

7.Sato Y,Seo N,Kobayashi E.Ethanol-induced hypnotic tolerance is absent in N-methyl-D-aspartate receptor ε1 subunit knockout mice.Anesth Analg,2006,103:117-120

8.Yin HH,Park BS,Adermark L,et al.Ethanol reverses the direction of long-term synaptic plASTicity in the dorsomedial striatum.Eur J Neurosci,2007,25:3226-3232

9.Wang J,Carnicella S,Phamluong K,et al.Ethanol induces long-term facilitation of NR2B-NMDA receptor activity in the dorsal striatum: implications for alcohol drinking behavior.Neurosci,2007,27:3593-3602

10.Szumlinski KK,Diab ME,Friedman R,et al.Accumbens neurochemical adaptations produced by binge-like alcohol consumption.Psychopharmacology,2007,190(3):415-431

11.Zuo GC,Yang JY,Hao Y,et al.Ethanol and acetaldehyde induce similar changes in extracellular levels of glutamate,taurine and GABA in rat anterior cingulate cortex.Toxicol Lett,2007,169:253-258

12.Zhu W,Bie B,Pan ZZ.Involvement of non-NMDA glutamate receptors in central amygdala in synaptic actions of ethanol and ethanol-induced reward behavior.Neurosci,2007,27:289-298

13.Bönsch D,Lenz B,Fiszer R,et al.Lowered DNA methyltransferase(DNMT-3b)mRNA expression is associated with genomic DNA hypermethylation in patients with chronic alcoholism.Neural Transm,2006,113:1299-1304

14.Bleich S,Lenz B,Ziegenbein M,et al.Epigenetic DNA hypermethylation of the HERP gene promoter induces down-regulation of its mRNA expression in patients with alcohol dependence.Alcohol Clin Exp Res,2006,30:587-591

15.Bardag-Gorce F,French BA,Joyce M,et al.Histone acetyltransferase p300 modulates gene expression in an epigenetic manner at high blood alcohol levels.Exp Mol Pathol,2007,82:197-202

16.Bardag-Gorce F,Oliva J,Dedes J,et al.Chronic ethanol feeding alters hepatocyte memory which is not altered by acute feeding.Alcohol Clin Exp Res,2009,33:684-692

17.Biermann T,Reulbach U,Lenz B,et al.N-methyl-D-aspartate 2b receptor subtype(NR2B)promoter methylation in patients during alcohol withdrawal.J Neural Transm,2009,116:615-622

18.Bleich S,Hillemacher T.Homocysteine,alcoholism and its molecular networks.Pharmacopsychiatry,2009,S102-109

19.Balae S,Marcos M,Szabo G.Emerging role of microRNAs in liver diseases.World J GASTroenterol,2009,15:5633-5640

20.Cowmeadow RB,Krishnan HR,Atkinson NS.The slowpoke gene is necessary for rapid ethanol tolerance in Drosophila.Alcohol Clin Exp Res,2005,29:1777-1786

21.Delcuve GP,RASTegar M,Davie JR.Epigenetic Control J Cell Physiol,2009,219-243

22.Dolganiuc A,Petrasek J,Kodys K,et al.MicroRNA expression profile in Lieber-DeCarli dietinduced alcoholic and methionine choline deficient diet-induced nonalcoholic steatohepatitis models in mice.Alcohol Clin Exp Res,2009,33:1704-1710

23.Esfandiari F,Medici V,Wong DH,et al.Epigenetic regulation of hepatic endoplasmic reticulum stress pathways in the ethanol-fed cystathionine beta synthase-deficient mouse.Hepatology,2010,51(3):932-941

24.Feng J,Fan G.The role of DNA methylation in the central nervous system and neuropsychiatric disorders.Int Rev Neurobiol,2009,89:67-84

25.Goll MG,Kirpekar F,Maggert KA,et al.Methylation of tRNA Asp by the DNA methyltransferase homolog Dnmt2.Science,2006,311:395-398

26.Grayson DR,Kundakovic M,Sharma RP.Is there a future for histone deacetylase inhibitors in the pharmacotherapy of psychiatric disorders? Mol Pharmacol,2010,77:126-135

27.Hillemacher T,Frieling H,Luber K,et al.Epigenetic regulation and gene expression of vasopressin and atrial natriuretic peptide in alcohol withdrawal.Psychoneuro-endocrinology,2009,34:555-560

28.Hillemacher T,Frieling H,Hartl T,et al.Promoter specific methylation of the dopamine transporter gene is altered in alcohol dependence and associated with craving.J Psychiatr Res,2009,43(4):388-392

29.Haycock PC,Ramsay M.Exposure of mouse embryos to ethanol during preimplantation development: effect on DNA methylation in the h19 imprinting control region.Biol Reprod,2009,81(4):618-627

30.Haycock PC.Fetal alcohol spectrum disorders: the epigenetic perspective.Biol Reprod,2009,81(4):607-617

31.Liu J,Asuncion-Chin M,Liu P,et al.CaM kinase Ⅱ phosphorylation of slo Thr107 regulates activity and ethanol responses of BK channels.Nat Neurosci,2006,9:41-49

32.Lee YJ,Shukla SD.Histone H3 phosphorylation at serine 10 and serine 28 is mediated by p38 MAPK in rat hepatocytes exposed to ethanol and acetaldehyde.Eur J Pharmacol,2007,573:29-38

33.Liu Y,Balaraman Y,Wang G,et al.Alcohol exposure alters DNA methylation profiles in mouse embryos at early neurulation.Epigenetics,2009,4:500-511

34.Lambert MP,Paliwal A,Vaissière T,et al.Aberrant DNA methylation distinguishes hepatocellular carcinoma associated with HBV and HCV infection and alcohol intake.J Hepatol,2011,54:705-715

35.Miranda TB,Jones PA.DNA methylation:the nuts and bolts of repression.J Cell Physiol,2007,213:384-390

36.Muschler MA,Hillemacher T,Kraus C,et al.DNA methylation of the POMC gene promoter is associated with craving in alcohol dependence.J Neural Transm,2010,117:513-519

37.Mandrekar P.Epigenetic regulation in alcoholic liver disease.World J GASTroenterol,2011,17(20):2456-2464

38.Ouko LA,Shantikumar K,Knezovich J,et al.Effect of alcohol consumption on CpG methylation in the differentially methylated regions of H19 and IG-DMR in male gametes-implications for fetal alcohol spectrum disorders.Alcohol Clin Exp Res,2009,33(9):1615-1627

39.Philibert RA,Gunter TD,Beach SR,et al.MAOA methylation is associated with nicotine and alcohol dependence in women.Am J Med Genet B Neuropsychiatr Genet,2008,147B:565-570

40.Pandey SC,Ugale R,Zhang H,et al.Brain chromatin remodeling: a novel mechanism of alcoholism.Neurosci,2008,28:3729-3737

41.Pietrzykowski AZ,Friesen RM,Martin GE,et al.Posttran-scriptional regulation 30.of BK channel splice variant stability by miR-9 underlies neuroadaptation to alcohol.Neuron,2008,59:274-287

42.Ponting CP,Oliver PL,Reik W.Evolution and functions of long noncoding RNAs.Cell,2009,136(4):629-641

43.Park BY,Lee BC,Jung KH,et al.Epigenetic changes of serotonin transporter in the patients with alcohol dependence: methylation of an serotonin transporter promoter CpG island.Psychiatry Investig,2011,8(2):130-133

44.Sathyan P,Golden HB,Miranda RC.Competing interactions between micro-RNAs determine neural progenitor survival and proliferation after ethanol exposure: evidence from an ex vivo model of the fetal cerebral cortical neuroepithelium.J Neurosci,2007,27:8546-8557

45.Shukla SD,Lee YJ,Park PH,et al.Acetaldehyde alters MAP kinase signalling and epigenetic histone modifications in hepatocytes.Novartis Found Symp,2007,285:217-228

46.Shukla SD,Velazquez J,French SW,et al.Emerging role of epigenetics in the actions of alcohol.Alcohol Clin Exp Res,2008,32(9):1525-1534

47.Tang Y,Banan A,Forsyth CB,et al.Effect of alcohol on miR-212 expression in intestinal epithelial cells and its potential role in alcoholic liver disease.Alcohol Clin Exp Res,2008,32:355-364

48.Vaissière T,Sawan C,Herceg Z.Epigenetic interplay between histone modifications and DNA methylation in gene silencing.Mutat Res,2008,659:40-48

49.Wang Y,Ghezzi A,Yin JC,et al.CREB regulation of BK channel gene expression underlies rapid drug tolerance.Genes Brain Behav,2009,8:369-376

50.Zhou FC,Balaraman Y,Teng M,et al.Alcohol alters DNA methylation patterns and inhibits neural stem cell differentiation.Alcohol Clin Exp Res,2011,35(4):735-746

51.Diako Charles,McMahon Kenneth,Mattinson Scott,et.al.Alcohol,Tannins,and Mannoprotein and their Interactions Influence the Sensory Properties of Selected Commercial Merlot Wines: A Preliminary Study.Journal of food science,2016,Vol.81(8):S2039-S2048

52.María-Pilar Sáenz-Navajas,Campo E,José Miguel Avizcuri,et al.Contribution of nonvolatile and aroma fractions to in-mouth sensory properties of red wines: wine reconstitution strategies and sensory sorting task.Anal Chim Acta,2012.Jun 30; 732:64-72

53.Buch S,Stickel F,Trepo E,et al.A genome-wide association study confirms PNPLA3 and identifies TM6SF2 and MBOAT7 as risk loci for alcohol-related cirrhosis.Nature Genetics.2015 Dec; 47(12):1443-1448

54.Manchiero C,Nunes AKDS,Magri MC,et al.The rs738409 polymorphism of the PNPLA3 gene is associated with hepatic steatosis and fibrosis in Brazilian patients with chronic hepatitis C.BMC Infect Dis.2017 Dec 19; 17(1):780

55.Rodrigues A,Ricardo-Da-Silva J M,Lucas C,et al.Effect of commercial mannoproteins on wine colour and tannins stability.Food Chemistry,2012,131(3):907-914